The discovery of pancreatic cancer subtypes has been a significant step forward in our mission to understand more about this disease and treat it better. It also means that this disease is more personal to a patient than we could have imagined – right down to the molecular level.
Because of this, researchers believe the future of treating pancreatic cancer is in personalized medicine, which enables doctors to tailor treatment plans specifically to an individual patient based on disease subtypes and other medical considerations.
Enter PASS-01: an exciting collaboration between a group of the foremost cancer centres in North America focused on exploring personalized medicine in pancreatic cancer using cutting-edge organoid technology.
We have brought together some of the finest pancreatic cancer researchers in North America; the time is right to dig in much deeper to help understand pancreatic cancer. We need to stop assuming one size fits all and instead advance the field by gaining a better understanding of every tumour. We believe our work can help doctors treat patients optimally today while providing a better understanding of this deadly disease into the near future.
The next frontier in patient care
Through the use of genomic analysis and organoid technology, PASS-01 aims to determine potential predictors of patient response to chemotherapy, as well as the identification of specific biomarkers that indicate which pancreatic cancer responds better to one treatment or another.
What is an organoid?
Organoids are an innovative way of providing personalized medicine: created using a patient’s own cancer cells to make a collection of “tumour avatars”, researchers are able to test 100+ treatments on the cancer cells at the same time, enabling them to quickly see which treatment would be most effective for each patient. The efficiency of using organoids is a powerful tool in the fight against pancreatic cancer – a disease that moves so swiftly that patients have no time to waste. PASS-01 will couple this expedited approach with access to novel therapies which will not only result in better treatment decisions for patients in real time, but help doctors make more informed treatment decisions faster on a broad scale in the future.
What are the goals of this trial?
Give patients more time with their loved ones and better quality of life through access to novel drugs they might not otherwise receive.
Increase our foundational understanding about the different subtypes of pancreatic cancer and the efficacy of potential biomarkers to help inform treatment plans for future patients.
Support personalized medicine becoming standard of care, giving each pancreatic cancer patient the best possible outcome based on their subtype.
Building on a legacy of promising research
Updated from Dr. Jennifer Knox, Primary Investigator, on the progress of the PASS-01 Trial, Fall 2022
One good example is a man who was benefitting from the chemotherapy. It was working modestly but he was having a lot of side effects. The tumour model we grew from his cancer suggested that a different drug might be more effective. We switched it up and suddenly he tolerates chemotherapy much better, and we get a better response – we get more shrinkage of the tumour. Another example that comes to mind, we find a rare mutation in the genome of a man’s pancreas cancer which we wouldn’t have thought to look for. We were able to find a trial that targeted that mutation and now after chemotherapy, he is doing really well with response to the targeted approach. Both of those would never have happened outside of this study.
PASS-01 is benefiting patients right now, while helping us increase our understanding of pancreatic cancer and how different subtypes of the disease respond to various treatments. In addition to the progress we’re seeing in the prognosis and quality of life of patients, other important advancements are being made as a result of this trial:
- PASS-01 researchers have discovered that 5% of pancreatic cancer patients have a specific mutation that appears to indicate a better prognosis. Five percent is not insignificant for a cancer like pancreatic where biomarkers are few and far between.
- Scientists have developed new software through the PASS-01 study that significantly increases the speed and capacity for screening tumour samples.
- Based on insights learned through PASS-01, investigators are considering development of AI tools that will allow for more immediate assessment of a tumour’s sensitivity to a broader range of therapies.
- The level of collaboration between leading cancer centers working across geographic borders, healthcare systems, and institutions has been tremendously successful and is setting a standard for future studies.
An International Effort
PASS-01 By the Numbers
Participating Research Centres
316-4211 Yonge Street
Toronto, ON M2P 2A9
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